منابع مشابه
Structure and function of cardiac potassium channels.
Recent advances in molecular biology have had a major impact on our understanding of the biophysical and molecular properties of ion channels. This review is focused on cardiac potassium channels which, in general, serve to control and limit cardiac excitability. Approximately 60 K+ channel subunits have been cloned to date. The (evolutionary) oldest potassium channel subunits consist of two tr...
متن کاملMitochondrial potassium channels: from pharmacology to function.
Mitochondrial potassium channels, such as ATP-regulated or large conductance Ca2+ -activated and voltage gated channels were implicated in cytoprotective phenomenon in different tissues. Basic effects of these channels activity include changes in mitochondrial matrix volume, mitochondrial respiration and membrane potential, and generation of reactive oxygen species. In this paper, we describe t...
متن کاملNeuronal sodium and potassium channels: structure and function.
Information transfer over long distances within the central nervous system is achieved because neurones are capable of generating and conducting action potentials. Such action potentials are the all or none signals or messages of the nervous system and depend on the operation of specialized membrane proteins called ion channels. More than 50 years ago, Cole and Curtis [16] showed that the elect...
متن کاملP13: Potassium Channels and Long-Term Potentiation Formation
Long-term potentiation (LTP) is a form of activity-dependent plasticity that occurs during learning. Potassium channels are the most diverse group of all ion channels that related to synaptic plasticity. Small-conductance calcium-activated potassium channels (SKs) are found in hippocampal CA1 neurons and by inhibiting of postsynaptic potentials are involved in synaptic transmission impairment. ...
متن کاملInward rectifier potassium channels. Cloning, expression and structure-function studies.
A PCR-based cloning strategy was used to identify novel subunits of the two-transmembrane domain inward rectifier potassium channel family from rat brain, heart, and skeletal muscle. When expressed in Xenopus oocytes, two of these clones (Kir4.1 and Kir2.3) gave rise to inwardly rectifying potassium currents. Two-electrode voltage clamp commands to potentials negative to EK evoked inward potass...
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ژورنال
عنوان ژورنال: Seminars in Cell & Developmental Biology
سال: 2007
ISSN: 1084-9521
DOI: 10.1016/j.semcdb.2007.05.008